Grm5^tm1Fcq
Targeted Allele Detail

Summary

• Symbol: Grm5^tm1Fcq
• Name: glutamate receptor, metabotropic 5; targeted mutation 1, Francois Conquet
• MGI ID: MGI:3575086
• Synonyms: mGlu5-, mGluR5^-
• Gene: Grm5 Location: Chr7:87233376-87784115 bp, + strand Genetic Position: Chr7, 49.01 cM
• Alliance: Grm5^tm1Fcq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neo into the last exon resulted in the deletion of 360 bp of coding sequence. Absence of transcript and protein were confirmed in mutant mice by Northern and Western blot analyses, respectively. (J:97042, J:97288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm5 Mutation: 75 strains or lines available

References

• Original: J:97288 Chiamulera C, et al., Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci. 2001 Sep;4(9):873-4
• All: 7 reference(s)