Hmgb3^tm1Dmb
Targeted Allele Detail

Summary

• Symbol: Hmgb3^tm1Dmb
• Name: high mobility group box 3; targeted mutation 1, David M Bodine
• MGI ID: MGI:3574779
• Synonyms: Hmgb3^-
• Gene: Hmgb3 Location: ChrX:70599523-70604261 bp, + strand Genetic Position: ChrX, 36.92 cM, cytoband A1
• Alliance: Hmgb3^tm1Dmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96514
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding exons were replaced with a PGK-neo cassette flanked by loxP sites. Northern blot of adult bone marrow confirmed absence of mutant males. (J:96514)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb3 Mutation: 5 strains or lines available

References

• Original: J:96514 Nemeth MJ, et al., Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors. Blood. 2005 Jan 15;105(2):627-34
• All: 2 reference(s)