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Txnrd1tm1.1Marc
Targeted Allele Detail
Nomenclature
Symbol: Txnrd1tm1.1Marc
Name: thioredoxin reductase 1; targeted mutation 1.1, Marcus Conrad
MGI ID: MGI:3574773
Synonyms: Txnrd1-
Gene: Txnrd1  Location: Chr10:82859206-82897724 bp, + strand  Genetic Position: Chr10, 40.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96818
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 15, which encodes 22 amino acids and the C-terminally located redox center consisting of Gly-Cys-Sec-Gly, and 1.7 kb of the 3' UTR containing the selenocysteine insertion element, essential for cotranslational Sec incorporation at the UGA codon, AU-rich mRNA instability elements and the endogenous transcription stop signal, were deleted from Txnrd1tm1Marc via cre-mediated recombination. RT-PCR confirmed the excision of exon 15 in embryonic mRNAs from E9.5 (J:96818)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txnrd1 Mutation:  37 strains or lines available
References
Original:  J:96818 Jakupoglu C, et al., Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol. 2005 Mar;25(5):1980-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory