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Targeted Allele Detail
Symbol: Hgftm1Jmw
Name: hepatocyte growth factor; targeted mutation 1, James M Wilson
MGI ID: MGI:3574633
Synonyms: HGFex.5-flox
Gene: Hgf  Location: Chr5:16553495-16620152 bp, + strand  Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
Germline Transmission:  Earliest citation of germline transmission: J:97145
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA single loxP site was inserted into intron 4 and a loxP-flanked neomycin-thymidine kinase selection cassette into intron 5 of the gene. The loxP sites flank a region of the gene encoding most of the first kringle domain necessary for the biological activity of the corresponding protein. Transient Cre recombinase transfection removed the selection cassette prior to the production of chimeric mice. (J:97145)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hgf Mutation:  19 strains or lines available
Original:  J:97145 Phaneuf D, et al., Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration. DNA Cell Biol. 2004 Sep;23(9):592-603
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory