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Targeted Allele Detail
Symbol: Barx2tm1Rsd
Name: BarH-like homeobox 2; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:3574438
Synonyms: Barx2-
Gene: Barx2  Location: Chr9:31846044-31913462 bp, - strand  Genetic Position: Chr9, 17.25 cM
Barx2tm1Rsd/Barx2tm1Rsd mice display open eyelids at birth, abnormal hair follicle remodeling and short whiskers and hair

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:96883
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ-PGK-neo replaced the 3' end of exon 2 and all of exon 3. The deleted sequence encoded the homeodomain and C-terminal sequence. RT-PCR of mutant skin samples demonstrated the loss of 3' message. The truncated transcript consisted of a 134 amino acid epitope fused in frame to Beta-galactosidase. (J:96883)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 62 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Barx2 Mutation:  9 strains or lines available
Original:  J:96883 Olson LE, et al., Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3708-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory