Barx2tm1Rsd
Targeted Allele Detail
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Symbol: |
Barx2tm1Rsd |
Name: |
BarH-like homeobox 2; targeted mutation 1, Michael G Rosenfeld |
MGI ID: |
MGI:3574438 |
Synonyms: |
Barx2- |
Gene: |
Barx2 Location: Chr9:31757340-31824581 bp, - strand Genetic Position: Chr9, 17.25 cM
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Alliance: |
Barx2tm1Rsd page
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Barx2tm1Rsd/Barx2tm1Rsd mice display open eyelids at birth, abnormal hair follicle remodeling and short whiskers and hair
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:96883
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A lacZ-PGK-neo replaced the 3' end of exon 2 and all of exon 3. The deleted sequence encoded the homeodomain and C-terminal sequence. RT-PCR of mutant skin samples demonstrated the loss of 3' message. The truncated transcript consisted of a 134 amino acid epitope fused in frame to Beta-galactosidase.
(J:96883)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Barx2 Mutation: |
26 strains or lines available
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Original: |
J:96883 Olson LE, et al., Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3708-13 |
All: |
6 reference(s) |
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