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Spry1tm1.1Jdli
Targeted Allele Detail
Nomenclature
Symbol: Spry1tm1.1Jdli
Name: sprouty homolog 1 (Drosophila); targeted mutation 1.1, Jonathan D Licht
MGI ID: MGI:3574404
Synonyms: Spry1-
Gene: Spry1  Location: Chr3:37639947-37644598 bp, + strand  Genetic Position: Chr3, 18.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96485
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCrossing Spry1tm1Jdli to cre deleter mice removed the entire coding sequence. RT-PCR of newborn kidney extracts demonstrated the absence of transcript in mutants. (J:96485)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spry1 Mutation:  5 strains or lines available
References
Original:  J:96485 Basson MA, et al., Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005 Feb;8(2):229-39
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory