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Targeted Allele Detail
Symbol: Ightm1(Myc)Janz
Name: immunoglobulin heavy chain complex; targeted mutation 1, Siegfried Janz
MGI ID: MGI:3574400
Synonyms: iMycEmu
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:96785
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Ightm1(Myc)Janz expresses 1 gene
Mutation detailsA His6-tagged Myc cDNA was inserted head to head into the locus 5' of the intronic enhancer Emu. This insertion of Myc mimics both the human t(8;14)(q24;q32) translocation that results in the activation of MYC in human endemic Burkitt lymphomas and the homologous mouse T(12;15) translocation that deregulates Myc in mouse plasmacytomas. (J:96785)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  33 strains or lines available
Original:  J:96785 Park SS, et al., Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res. 2005 Feb 15;65(4):1306-15
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory