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Septin4tm1Hs
Targeted Allele Detail
Summary
Symbol: Septin4tm1Hs
Name: septin 4; targeted mutation 1, Hermann Steller
MGI ID: MGI:3574368
Synonyms: Sept4-
Gene: Septin4  Location: Chr11:87457515-87481365 bp, + strand  Genetic Position: Chr11, 52.14 cM
Alliance: Septin4tm1Hs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96669
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details8 kb of sequence, almost the entire locus, was replaced with a neomycin resistance gene. Western blot confirmed the absence of isoforms H5 and M-Septin by probing cerebellum protein extracts from mutants with an antibody raised against a peptide from exon 1. (J:96669)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Septin4 Mutation:  42 strains or lines available
References
Original:  J:96669 Kissel H, et al., The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev Cell. 2005 Mar;8(3):353-64
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory