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Targeted Allele Detail
Symbol: Tnfrsf10btm1Wsed
Name: tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1, Wafik S El-Diery
MGI ID: MGI:3574360
Synonyms: DR5-
Gene: Tnfrsf10b  Location: Chr14:69767472-69784411 bp, + strand  Genetic Position: Chr14, 36.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:96816
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4 and part of 5 were replaced with a PGK-neo cassette in the reverse orientation, causing a downstream frame shift. The deleted sequence encompassed the extracellular domain of the gene and encoded the cystein-rich repeats. RT-PCR analysis of mutants confirmed the lack of functional gene transcription in small bowel extracts. (J:96816)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf10b Mutation:  23 strains or lines available
Original:  J:96816 Finnberg N, et al., DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol. 2005 Mar;25(5):2000-13
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory