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Targeted Allele Detail
Symbol: Adamts1tm1Mapr
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; targeted mutation 1, Melanie A Pritchard
MGI ID: MGI:3574351
Gene: Adamts1  Location: Chr16:85590715-85600001 bp, - strand  Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
Germline Transmission:  Earliest citation of germline transmission: J:96781
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 2 was deleted via cre-mediated recombination, removing the metalloproteinase domain and, if normal splicing occurred, would result in a frame shift leading to a truncated protein containing only a pre-/pro-domain only. Northern blot using a probe containing exons 4-8 indicated the absence of transcript. Immunohistochemistry further demonstrated the absence of expression in null ovaries. (J:96781)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adamts1 Mutation:  41 strains or lines available
Original:  J:96781 Mittaz L, et al., Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod. 2004 Apr;70(4):1096-105
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory