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Targeted Allele Detail
Symbol: Akt3tm1Mbb
Name: thymoma viral proto-oncogene 3; targeted mutation 1, Morris J Birnbaum
MGI ID: MGI:3574346
Synonyms: Ak3-, Akt3-
Gene: Akt3  Location: Chr1:177020073-177258203 bp, - strand  Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
Germline Transmission:  Earliest citation of germline transmission: J:96823
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence containing nucleotides 209-320 in exon 3 was replaced with a loxP flanked PGK-hygro-pA cassette, resulting in a frame shift in the ORF and a truncation of the resulting protein. Western blot of mutant brain tissue demonstrated that protein was undetectable. (J:96823)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt3 Mutation:  9 strains or lines available
Original:  J:96823 Easton RM, et al., Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol. 2005 Mar;25(5):1869-78
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory