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Tg(ITGAM-DTR/EGFP)34Lan
Transgene Detail
Nomenclature
Symbol: Tg(ITGAM-DTR/EGFP)34Lan
Name: transgene insertion 34, Richard A Lang
MGI ID: MGI:3574313
Synonyms: CD11b-DTR, tg(CD11b-DTR)Llan
Transgene: Tg(ITGAM-DTR/EGFP)34Lan  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the human ITGAM (integrin alpha M) promoter (CD11b), and human growth hormone sequence. Mice carrying this transgene have a diphtheria toxin (DT) inducible system that transiently depletes macrophages. RT-PCR analysis of bone marrow macrophages detects specific transgene expression. (J:95141)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
References
Original:  J:95141 Duffield JS, et al., Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005 Jan;115(1):56-65
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory