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Egr2tm1Jmi
Targeted Allele Detail
Nomenclature
Symbol: Egr2tm1Jmi
Name: early growth response 2; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:3574072
Synonyms: Egr2lo
Gene: Egr2  Location: Chr10:67535475-67542188 bp, + strand  Genetic Position: Chr10, 34.96 cM, cytoband B5
Runted phenotype and hindbrain defect of Egr2tm1Jmi/Egr2tm1Jmi mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96641
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
    This hypomorphic allele resulted from the insertion of a PGK-neo into intron 1. (J:96641)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr2 Mutation:  18 strains or lines available
References
Original:  J:96641 Le N, et al., Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2596-601
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory