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Targeted Allele Detail
Symbol: Hey1tm1Kkb
Name: hairy/enhancer-of-split related with YRPW motif 1; targeted mutation 1, Hiroki Kokubo
MGI ID: MGI:3574059
Synonyms: hesr1-
Gene: Hey1  Location: Chr3:8663359-8667256 bp, - strand  Genetic Position: Chr3, 2.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:96337
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe bHLH region, from exon 1 to exon 4, was replaced by a loxP-flanked neo. Crossing with mice expressing Cre-recombinase removed the neo. (J:96337)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hey1 Mutation:  9 strains or lines available
Original:  J:96337 Kokubo H, et al., Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15;278(2):301-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory