Hey1^tm1Kkb
Targeted Allele Detail

Summary

• Symbol: Hey1^tm1Kkb
• Name: hairy/enhancer-of-split related with YRPW motif 1; targeted mutation 1, Hiroki Kokubo
• MGI ID: MGI:3574059
• Synonyms: hesr1^-
• Gene: Hey1 Location: Chr3:8728419-8732098 bp, - strand Genetic Position: Chr3, 2.15 cM
• Alliance: Hey1^tm1Kkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96337
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The bHLH region, from exon 1 to exon 4, was replaced by a loxP-flanked neo. Crossing with mice expressing Cre-recombinase removed the neo. (J:96337)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey1 Mutation: 17 strains or lines available

References

• Original: J:96337 Kokubo H, et al., Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15;278(2):301-9
• All: 12 reference(s)