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Itga10tm1Ref
Targeted Allele Detail
Nomenclature
Symbol: Itga10tm1Ref
Name: integrin, alpha 10; targeted mutation 1, Reinhard Fassler
MGI ID: MGI:3574026
Gene: Itga10  Location: Chr3:96645584-96664513 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96524
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn EGFP and loxP flanked neo were inserted to replace exon 1. RT-PCR of hearts from mutant mice demonstrated the lack of transcript. Loss of protein was further confirmed by Western blot of chondrocyte lysates and immunostaining of newborn knee cartilage. (J:96524)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga10 Mutation:  48 strains or lines available
References
Original:  J:96524 Bengtsson T, et al., Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci. 2005 Mar 1;118(Pt 5):929-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory