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Targeted Allele Detail
Symbol: Sntb2tm1Maad
Name: syntrophin, basic 2; targeted mutation 1, Marvin E Adams
MGI ID: MGI:3574023
Synonyms: beta2SynKO
Gene: Sntb2  Location: Chr8:106935740-107014232 bp, + strand  Genetic Position: Chr8, 53.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:96569
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo replaced exon 1, amino acids 1-173 which encode half of the first PH domain and the entire PDZ domain. Immunoblot confirmed the absence of protein in mutant muscle extracts. (J:96569)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sntb2 Mutation:  58 strains or lines available
Original:  J:96569 Adams ME, et al., Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. J Neurosci. 2004 Nov 17;24(46):10302-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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