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Edn1tm1.1Ywa
Targeted Allele Detail
Nomenclature
Symbol: Edn1tm1.1Ywa
Name: endothelin 1; targeted mutation 1.1, Masashi Yanagisawa
MGI ID: MGI:3573945
Synonyms: dlox, Edn1tm1Hhua, ET-1dlox
Gene: Edn1  Location: Chr13:42301476-42307990 bp, + strand  Genetic Position: Chr13, 20.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96386
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2, and a neo-thymidine kinase selection cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. (J:96386, J:196635)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edn1 Mutation:  24 strains or lines available
References
Original:  J:96386 Huang H, et al., Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin Sci (Lond). 2002 Aug;103 Suppl 48:263S-266S
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory