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Targeted Allele Detail
Symbol: Tiraptm1Medz
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; targeted mutation 1, Ruslan Medzhltov
MGI ID: MGI:3573942
Synonyms: Tirap-, TIRAPtm1MD
Gene: Tirap  Location: Chr9:35095847-35111587 bp, - strand  Genetic Position: Chr9, 19.99 cM, cytoband A5.3
Germline Transmission:  Earliest citation of germline transmission: J:96773
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 640 bp exon encoding most of the coding sequence. RT-PCR of mutant mice confirmed absence of transcript. (J:96773)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tirap Mutation:  12 strains or lines available
Original:  J:96773 Horng T, et al., The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 2002 Nov 21;420(6913):329-33
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory