Smc1b^tm1Jess
Targeted Allele Detail

Summary

• Symbol: Smc1b^tm1Jess
• Name: structural maintenance of chromosomes 1B; targeted mutation 1, Rolf Jessberger
• MGI ID: MGI:3573932
• Synonyms: Smc1Beta^-
• Gene: Smc1b Location: Chr15:84948890-85016158 bp, - strand Genetic Position: Chr15, 40.25 cM, cytoband E3
• Alliance: Smc1b^tm1Jess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96769
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10, which codes for 40% of the hinge domain, essential to the formation of Smc heterodimers, was targeted for replacement by a tk-neo cassette. Immunoblotting of testis nuclear extracts confirmed the absence of wild-type protein. (J:96769)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smc1b Mutation: 69 strains or lines available

References

• Original: J:96769 Revenkova E, et al., Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination. Nat Cell Biol. 2004 Jun;6(6):555-62
• All: 17 reference(s)