Gt(ROSA)26Sor^{tm1(Gphb5)Lmac}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Gphb5)Lmac}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Lynn E Macdonald
• MGI ID: MGI:3573780
• Synonyms: OGH-TG
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Gphb5)Lmac} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96633
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Gphb5)Lmac} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gphb5 (MGI:2156540)

• Mutation details: A vector containing the adenovirus splice acceptor, the Gphb5 coding sequence, rabbit Beta-globin polyA, PGK promoter, Tn5neo and PGK polyA was inserted into the Gt(ROSA)26Sor locus. (J:96633)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:96633 Macdonald LE, et al., Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501
• All: 1 reference(s)