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Tg(Ins2-GP)34-20Olds
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-GP)34-20Olds
Name: transgene insertion 34-20, Michael BA Oldstone, MD
MGI ID: MGI:3573699
Synonyms: LCMV GP, RIP GP34-20, RIP-GP34-20, RIP GP H2b, RIP-LCMV GP
Transgene: Tg(Ins2-GP)34-20Olds  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x BALB/Wehi)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene encodes the glycoprotein (GP) from Armstrong's clone of the lymphocytic choriomeningitis virus (LCMV) regulated by the rat insulin promoter. Upstream of the GP cDNA are 660 base pairs of regulatory elements in addition to the rat insulin promoter. Downstream of the GP c-DNA is the SV40 small T-antigen intron and late polyadenylation signal. RT-PCR analysis demonstrated that the transcript was expressed in the pancreas but not the thymus, spleen, liver, kidney, heart, muscle or lung. (J:81287)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:81287 von Herrath MG, et al., How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity. 1994 Jun;1(3):231-42
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory