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Targeted Allele Detail
Symbol: Dmdtm1.1Khan
Name: dystrophin, muscular dystrophy; targeted mutation 1.1, Kazunori Hanaoka
MGI ID: MGI:3531484
Gene: Dmd  Location: ChrX:82948870-85206141 bp, + strand  Genetic Position: ChrX, 38.38 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:96210
Parent Cell Line:  TT2F (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was produced from Dmdtm1Khan. The entire 2.4 Mb Dmd gene was removed by transient expression of cre recombinase in correctly targeted ES cells. RT-PCR and Western blot analyses failed to detect any expressions of full-length and short isoforms in muscle, cerebrum, and cerebellum. (J:96210)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmd Mutation:  159 strains or lines available
Original:  J:96210 Kudoh H, et al., A new model mouse for Duchenne muscular dystrophy produced by 2.4Mb deletion of dystrophin gene using Cre-loxP recombination system. Biochem Biophys Res Commun. 2005 Mar 11;328(2):507-16
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory