Rnd3^{Gt(OST364657)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rnd3^{Gt(OST364657)Lex}
• Name: Rho family GTPase 3; gene trap OST364657, Lexicon Genetics
• MGI ID: MGI:3530138
• Synonyms: Rnd3^{Gt(IRESBetageo)380Lex}
• Gene: Rnd3 Location: Chr2:51020451-51039123 bp, - strand Genetic Position: Chr2, 29.63 cM
• Alliance: Rnd3^{Gt(OST364657)Lex} page

Smaller size and abnormal position of the hindlimbs in Rnd3^{Gt(OST364657)Lex}/Rnd3^{Gt(OST364657)Lex} mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: OST364657
• Germline Transmission: Earliest citation of germline transmission: J:172361
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• The gene trap vector inserted into intron 2. LacZ expression was detected in most embryonic tissues. (J:172361)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST364657	CG637560 ; (MGI Seq Detail)	3' RACE	Chr2:51022271-51027253 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Schematic of the insertion of the Rnd3^{Gt(OST364657)Lex} gene-trap vector

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rnd3 Mutation: 29 strains or lines available

References

• Original: J:172361 Mocholi E, et al., RhoE Deficiency Produces Postnatal Lethality, Profound Motor Deficits and Neurodevelopmental Delay in Mice. PLoS One. 2011;6(4):e19236
• All: 6 reference(s)