Ccnd1^{tm2(Ccnd2)Pisc}
Targeted Allele Detail

Summary

• Symbol: Ccnd1^{tm2(Ccnd2)Pisc}
• Name: cyclin D1; targeted mutation 2, Piotr Sicinski
• MGI ID: MGI:3530077
• Synonyms: Ccnd1^{tm1(Ccnd2)Pisc}
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^{tm2(Ccnd2)Pisc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95994
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 1-4 were replaced by the full-length Ccnd2 cDNA and a PGK-neo. Western blot of mutant spleen and kidney confirmed the lack of Ccnd1 protein and presence of Ccnd2 protein. (J:95994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 21 strains or lines available

References

• Original: J:95994 Carthon BC, et al., Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb;25(3):1081-8
• All: 2 reference(s)