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Targeted Allele Detail
Symbol: Klf10tm1Sub
Name: Kruppel-like factor 10; targeted mutation 1, Malayannan Subramaniam
MGI ID: MGI:3530069
Synonyms: KLF10-, TIEG-
Gene: Klf10  Location: Chr15:38291463-38300706 bp, - strand  Genetic Position: Chr15, 15.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:95992
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2, including transcription and translation start sites and the first 114 amino acids, were replaced with a neo cassette with a polyA signal. Northern blot of mutants confirmed absence of transcript and immunoprecipitation demonstrated the lack of protein in mutants. (J:95992)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf10 Mutation:  4 strains or lines available
Original:  J:95992 Subramaniam M, et al., TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol. 2005 Feb;25(3):1191-9
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory