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Transgene Detail
Symbol: Tg(Th-SNCA)5Eric
Name: transgene insertion 5, Eric K Richfield
MGI ID: MGI:3530029
Synonyms: hwalpha-SYN-5, Tg(Th-SNCA)5Fed, THsynWT
Transgene: Tg(Th-SNCA)5Eric  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Th-SNCA)5Eric expresses 1 gene
Mutation detailsThe transgene contains a 9 kb rat tyrosine hydroxylase promoter, a splice donor/intron/splice acceptor, a poly(A) site from the human growth hormone gene, and a wild-type human alpha synuclein cDNA. RT-PCR detected transgene expression in midbrain, eye, and adrenal gland. Real time quantitative RT-PCR as well as in situ hybridization histochemistry detected high levels of transgene expression in the midbrain. Catecholaminergic nuclei in the brain of transgenic mice expressed both human mRNA and human protein. These mice express high levels of the human protein in the cell bodies of dopaminergic neurons in the midbrain and its main projection region, the striatum, dopaminergic dendrites, and nigrostriatal axons and terminals. (J:76482)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Line 88 was also generated using this wild-type construct.

Original:  J:76482 Richfield EK, et al., Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002 May;175(1):35-48
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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