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Dtx1tm1Crey
Targeted Allele Detail
Nomenclature
Symbol: Dtx1tm1Crey
Name: deltex 1, E3 ubiquitin ligase; targeted mutation 1, Claude-Agnes Reynaud
MGI ID: MGI:3530026
Synonyms: Deltex-1delta
Gene: Dtx1  Location: Chr5:120680202-120711927 bp, - strand  Genetic Position: Chr5, 60.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95986
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neo replaced exons 4-10 (G321 to A626), which encode the C-terminal half of the protein that includes the RING finger domain. Northern blot showed the presence of three new transcripts. The longest form putatively corresponds to a partially spliced mRNA stabilized by the polyA signal of neo. The shortest form was suggested to be created by splicing of the donor site of exon 3 to a cryptic acceptor site in the neo, which created an in-frame stop codon 7 amino acids downstream. It could not be determined if a truncated protein without the RING finger domain was expressed. (J:95986)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dtx1 Mutation:  22 strains or lines available
References
Original:  J:95986 Storck S, et al., Normal immune system development in mice lacking the Deltex-1 RING finger domain. Mol Cell Biol. 2005 Feb;25(4):1437-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory