Pik3c2a^{Gt(OST288105)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Pik3c2a^{Gt(OST288105)Lex}
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; gene trap OST288105, Lexicon Genetics
• MGI ID: MGI:3529840
• Synonyms: Pik3c2a^{Gt(neo)268Lex}
• Gene: Pik3c2a Location: Chr7:115936500-116042684 bp, - strand Genetic Position: Chr7, 61.62 cM
• Alliance: Pik3c2a^{Gt(OST288105)Lex} page

Mutation origin

• Mutant Cell Line: OST288105
• Germline Transmission: Earliest citation of germline transmission: J:94338
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted into intron 27. The expression of a truncated protein product, missing the 267 amino C-terminal amino acids, was confirmed by western blot analysis. Reduced enzymatic activity was confirmed in the liver and kidney. (J:169710)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST288105	CG608214 ; (MGI Seq Detail)	3' RACE	Chr7:115941446-115945475 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3c2a Mutation: 97 strains or lines available

References

• Original: J:94338 NIH Mouse Knockout Inventory, Information obtained from the NIH Mouse Knockout Inventory. MGI Direct Data Submission. 2004
• All: 5 reference(s)