Trmq5^RIIIS/J
QTL Variant Detail

Summary

• QTL variant: Trmq5^RIIIS/J
• Name: T cell ratio modifier QTL 5; RIIIS/J
• MGI ID: MGI:3529509
• QTL: Trmq5 Location: unknown Genetic Position: Chr3, cM position of peak correlated region/allele: 38.19 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: RIIIS/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased CD4:CD8 T cell ratios compared to B10.RIII. (J:95848)
• Inheritance: Recessive

Notes

Homozygosity for RIIIS/J-derived alleles at both Trmq4 and Trmq5 confer increased CD4+/CD8+ T cell ratios.

References

• Original: J:95848 Karlsson J, et al., Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. J Immunol. 2005 Jan 1;174(1):533-41
• All: 1 reference(s)