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Mcamtm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Mcamtm1Lex
Name: melanoma cell adhesion molecule; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528863
Gene: Mcam  Location: Chr9:44134469-44142727 bp, + strand  Genetic Position: Chr9, 24.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193167
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA selection cassette replaced the first three coding exons. Immunofluorescence analysis confirmed the absence of protein expression in alveolar macrophages from homozygous mice. (J:193167)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcam Mutation:  21 strains or lines available
References
Original:  J:193167 Wu Q, et al., A Novel Function of MUC18: Amplification of Lung Inflammation during Bacterial Infection. Am J Pathol. 2013 Mar;182(3):819-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory