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Chuktm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Chuktm1Lex
Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528766
Synonyms: IKKalphafl
Gene: Chuk  Location: Chr19:44073335-44107480 bp, - strand  Genetic Position: Chr19, 36.71 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159873
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 6 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. (J:159873)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chuk Mutation:  4 strains or lines available
References
Original:  J:159873 Penzo M, et al., Inhibitor of NK-kappaB kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis. J Immunol. 2010 Apr 15;184(8):4497-509
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory