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Targeted Allele Detail
Symbol: Csmd1tm1Lex
Name: CUB and Sushi multiple domains 1; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528558
Gene: Csmd1  Location: Chr8:15892537-17535586 bp, - strand  Genetic Position: Chr8, 8.38 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding portion of the first exon along with some first intron sequence was deleted and a selection cassette was inserted in its place after the homologous recombination event. This selection cassette contains a Beta-Galactosidase marker (LacZ) and a Neomycin resistance (Neo) fragment to allow selection in ES cells. qPCR confirmed reduced expression of transcripts containing exon 1 and 2 in the brain. Western blot analysis confirmed the absence of full-length protein expression in the cortex. (J:94077, J:194991, J:209700)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Csmd1 Mutation:  143 strains or lines available
Original:  J:194991 Distler MG, et al., Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice. PLoS One. 2012;7(12):e51235
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory