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Targeted Allele Detail
Symbol: Csmd1tm1Lex
Name: CUB and Sushi multiple domains 1; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528558
Gene: Csmd1  Location: Chr8:15892538-17535385 bp, - strand  Genetic Position: Chr8, 8.38 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding portion of the first exon along with some first intron sequence was deleted and a selection cassette was inserted in its place after the homologous recombination event. This selection cassette contains a Beta-Galactosidase marker (LacZ) and a Neomycin resistance (Neo) fragment to allow selection in ES cells. qPCR confirmed reduced expression of transcripts containing exon 1 and 2 in the brain. Western blot analysis confirmed the absence of full-length protein expression in the cortex. (J:94077, J:194991, J:209700)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Csmd1 Mutation:  158 strains or lines available
Original:  J:194991 Distler MG, et al., Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice. PLoS One. 2012;7(12):e51235
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.13
The Jackson Laboratory