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Tgm2tm1.1Rmgr
Targeted Allele Detail
Nomenclature
Symbol: Tgm2tm1.1Rmgr
Name: transglutaminase 2, C polypeptide; targeted mutation 1.1, Robert M Graham
MGI ID: MGI:3527996
Synonyms: TG2-, TGase 2-, Tgm2-, tTg-
Gene: Tgm2  Location: Chr2:158116402-158146436 bp, - strand  Genetic Position: Chr2, 78.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95130
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 6-8 were excised following cre-mediated excision. This sequence encoded the TGase catalytic core domain. Northern blot and RT-PCR both confirmed absence of transcript in mutant hearts. Lack of protein was demonstrated in mutant liver membranes and heart cytosol by Western blot analysis. (J:95130)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgm2 Mutation:  19 strains or lines available
References
Original:  J:95130 Nanda N, et al., Targeted inactivation of Gh/tissue transglutaminase II. J Biol Chem. 2001 Jun 8;276(23):20673-8
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory