Sema3e^tm1Ddg
Targeted Allele Detail

Summary

• Symbol: Sema3e^tm1Ddg
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, David D Ginty
• MGI ID: MGI:3527995
• Synonyms: sema3e^-
• Gene: Sema3e Location: Chr5:14075290-14306703 bp, + strand Genetic Position: Chr5, 5.66 cM
• Alliance: Sema3e^tm1Ddg page

The vascular network is disorganized in Sema3e^tm1Ddg/Sema3e^tm1Ddg retinas

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95697
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert an EGFP and a floxed neo at the start codon, deleting the signal peptide in exon 1. In situ hybridization confirmed the absence of mRNA in mutant mice. (J:95697)

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sema3e Mutation: 65 strains or lines available

References

• Original: J:95697 Gu C, et al., Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8
• All: 28 reference(s)