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Dok2tm1Yyam
Targeted Allele Detail
Nomenclature
Symbol: Dok2tm1Yyam
Name: docking protein 2; targeted mutation 1, Yuji Yamanashi
MGI ID: MGI:3527416
Gene: Dok2  Location: Chr14:70766037-70778494 bp, + strand  Genetic Position: Chr14, 36.71 cM, cytoband D2-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95335
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo-bpA cassette was used to disrupt the entire coding region, including the initiation and termination codons. Immunoblot analysis of bone marrow cells did not detect protein gene product. (J:95335)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok2 Mutation:  10 strains or lines available
References
Original:  J:95335 Yasuda T, et al., Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med. 2004 Dec 20;200(12):1681-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory