Zbtb32^tm2Ppp
Targeted Allele Detail

Summary

• Symbol: Zbtb32^tm2Ppp
• Name: zinc finger and BTB domain containing 32; targeted mutation 2, Pier Paolo Pandolfi
• MGI ID: MGI:3527275
• Synonyms: PLZP^lacZ
• Gene: Zbtb32 Location: Chr7:30289106-30298334 bp, - strand Genetic Position: Chr7, 18.72 cM, cytoband B2-B3
• Alliance: Zbtb32^tm2Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95119
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing lacZ, neo, and a t-Ace-cre construct was inserted in frame distal to the ATG. The t-Ace promoter allowed excision of the noe and cre during passage through the germ line. Northern blot of mutant testis demonstrated the presence of transcript and X-gal staining confirmed lacZ expression in the testis. (J:95119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb32 Mutation: 26 strains or lines available

References

• Original: J:95119 Piazza F, et al., Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Mol Cell Biol. 2004 Dec;24(23):10456-69
• All: 1 reference(s)