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Targeted Allele Detail
Symbol: Zbtb32tm2Ppp
Name: zinc finger and BTB domain containing 32; targeted mutation 2, Pier Paolo Pandolfi
MGI ID: MGI:3527275
Synonyms: PLZPlacZ
Gene: Zbtb32  Location: Chr7:30589681-30598909 bp, - strand  Genetic Position: Chr7, 18.72 cM, cytoband B2-B3
Germline Transmission:  Earliest citation of germline transmission: J:95119
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA cassette containing lacZ, neo, and a t-Ace-cre construct was inserted in frame distal to the ATG. The t-Ace promoter allowed excision of the noe and cre during passage through the germ line. Northern blot of mutant testis demonstrated the presence of transcript and X-gal staining confirmed lacZ expression in the testis. (J:95119)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zbtb32 Mutation:  6 strains or lines available
Original:  J:95119 Piazza F, et al., Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Mol Cell Biol. 2004 Dec;24(23):10456-69
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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