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Dok2tm1Ppp
Targeted Allele Detail
Nomenclature
Symbol: Dok2tm1Ppp
Name: docking protein 2; targeted mutation 1, Pier Paolo Pandolfi
MGI ID: MGI:3527246
Gene: Dok2  Location: Chr14:70766036-70778495 bp, + strand  Genetic Position: Chr14, 36.71 cM, cytoband D2-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95334
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by the insertion of a cassette containing EGFP and neo (in inverse orientation). Western blot analysis of splenocytes did not detect protein gene product. EGFP expression was not reported. (J:95334)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok2 Mutation:  8 strains or lines available
References
Original:  J:95334 Niki M, et al., Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med. 2004 Dec 20;200(12):1689-95
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory