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Targeted Allele Detail
Symbol: Akr1c18tm1Jni
Name: aldo-keto reductase family 1, member C18; targeted mutation 1, James N Ihle
MGI ID: MGI:3527218
Synonyms: 20alpha-HSD-
Gene: Akr1c18  Location: Chr13:4132615-4150654 bp, - strand  Genetic Position: Chr13, 2.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:95560
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3, encoding essential components of the enzyme's active site, were replaced with a neo in reverse transcription orientation. Western blot of mutant adrenal, kidney and ovary confirmed the lack of protein. (J:95560)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akr1c18 Mutation:  20 strains or lines available
Original:  J:95560 Piekorz RP, et al., Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol. 2005 Feb;19(2):431-40
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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