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Ctsktm1Vuo
Targeted Allele Detail
Nomenclature
Symbol: Ctsktm1Vuo
Name: cathepsin K; targeted mutation 1, Eero Vuorio
MGI ID: MGI:3527195
Synonyms: Ctsk-
Gene: Ctsk  Location: Chr3:95499256-95509362 bp, + strand  Genetic Position: Chr3, 40.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95525
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neo replaced exons 2-5. Northern and Western blot demonstrated the absence of transcript and protein, respectively, in mutant mice. (J:95525)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsk Mutation:  13 strains or lines available
References
Original:  J:95525 Kiviranta R, et al., Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone. 2005 Jan;36(1):159-72
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory