Ctsk^tm1Vuo
Targeted Allele Detail

Summary

• Symbol: Ctsk^tm1Vuo
• Name: cathepsin K; targeted mutation 1, Eero Vuorio
• MGI ID: MGI:3527195
• Synonyms: Ctsk^-
• Gene: Ctsk Location: Chr3:95406567-95416673 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctsk^tm1Vuo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95525
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neo replaced exons 2-5. Northern and Western blot demonstrated the absence of transcript and protein, respectively, in mutant mice. (J:95525)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsk Mutation: 29 strains or lines available

References

• Original: J:95525 Kiviranta R, et al., Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone. 2005 Jan;36(1):159-72
• All: 3 reference(s)