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Targeted Allele Detail
Symbol: Umodtm1Xrw
Name: uromodulin; targeted mutation 1, Xue-Ru Wu
MGI ID: MGI:3526897
Synonyms: THP-
Gene: Umod  Location: Chr7:119462711-119479282 bp, - strand  Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:95431
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1-4 and a 650 bp proximal promoter region were replaced with a neomycin cassette. RT-PCR and Northern blot analysis demonstrated the lack of transcript in mutant kidneys. Immunohistochemistry and Western blot showed that no protein was present in mutant mice. (J:95431)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Umod Mutation:  2 strains or lines available
Original:  J:95431 Mo L, et al., Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol. 2004 Apr;286(4):F795-802
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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