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Targeted Allele Detail
Symbol: Tlr1tm1Flv
Name: toll-like receptor 1; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3526882
Synonyms: TLR1-
Gene: Tlr1  Location: Chr5:64924811-64932761 bp, - strand  Genetic Position: Chr5, 33.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:95726
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsThe entire gene was replaced by a neomycin resistance cassette. Rt-PCR confirmed the absence of transcription. (J:95726)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr1 Mutation:  2 strains or lines available
Original:  J:95726 Alexopoulou L, et al., Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 2002 Aug;8(8):878-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory