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Targeted Allele Detail
Symbol: Abi2tm1Pen
Name: abl-interactor 2; targeted mutation 1, Ann Marie Pendergast
MGI ID: MGI:3526871
Synonyms: Abi2-
Gene: Abi2  Location: Chr1:60409619-60481158 bp, + strand  Genetic Position: Chr1, 30.47 cM
Germline Transmission:  Earliest citation of germline transmission: J:95254
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exons 2 and 3 with a PGK-neo. Immunoblot of MEFs or brains from mutants demonstrated a lack of protein. (J:95254)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abi2 Mutation:  22 strains or lines available
Original:  J:95254 Grove M, et al., ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol. 2004 Dec;24(24):10905-22
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory