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Prkcitm1Kido
Targeted Allele Detail
Nomenclature
Symbol: Prkcitm1Kido
Name: protein kinase C, iota; targeted mutation 1, Yoshiaki Kido
MGI ID: MGI:3526850
Synonyms: alphaPKClambdafloxE5, alphaPKClambdafloxed, PRClambdaflox
Gene: Prkci  Location: Chr3:30995742-31052740 bp, + strand  Genetic Position: Chr3, 14.65 cM
Focal segmental glomerulosclerosis in Prkcitm1Kido/Prkcitm1.1Kido Tg(Nphs1-cre)33Mska/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95378
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites flanked exon 5 by homologous recombination. (J:95378)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkci Mutation:  54 strains or lines available
References
Original:  J:95378 Hashimoto N, et al., PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest. 2005 Jan;115(1):138-45
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory