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Tg(Igh-6/Igh-V125)2Jwt
Transgene Detail
Nomenclature
Symbol: Tg(Igh-6/Igh-V125)2Jwt
Name: transgene insertion 2, James W Thomas
MGI ID: MGI:3526723
Synonyms: 125HC, 125Tg, 125VH, VH125, VH125Tg, VH Tg125
Transgene: Tg(Igh-6/Igh-V125)2Jwt  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-6/Igh-V125)2Jwt expresses 2 genes
 
Mutation detailsThis construct encodes an IgMa constant region with the variable specificity from BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 that was the source of the immunoglobulin heavy chain VDJ sequence in this transgene. The resulting antibody binds insulin when co-expressed with a transgene encoding the light chain with the VJ of mAB125. (J:91866)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:91866 Rojas M, et al., Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. J Immunol. 2001 Mar 1;166(5):3194-200
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory