Parg^tm1Tmd
Targeted Allele Detail

Summary

• Symbol: Parg^tm1Tmd
• Name: poly (ADP-ribose) glycohydrolase; targeted mutation 1, Ted M Dawson
• MGI ID: MGI:3526553
• Synonyms: PARG^-
• Gene: Parg Location: Chr14:31923906-32019507 bp, + strand Genetic Position: Chr14, 19.4 cM, cytoband B
• Alliance: Parg^tm1Tmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing IRES-lacZ-MCneomycin replaced the 3' end of exon 4. RT-PCR analysis of total RNA from mutant embryonic trophoblast stem cells demonstrated a lack of all reported splice variants. Western blot showed the complete absence of protein. (J:95214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parg Mutation: 68 strains or lines available

References

• Original: J:95214 Koh DW, et al., Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17699-704
• All: 2 reference(s)