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Sdhdtm1Jlob
Targeted Allele Detail
Summary
Symbol: Sdhdtm1Jlob
Name: succinate dehydrogenase complex, subunit D, integral membrane protein; targeted mutation 1, Jose Lopez-Barneo
MGI ID: MGI:3526521
Synonyms: SDHD-
Gene: Sdhd  Location: Chr9:50507657-50515112 bp, - strand  Genetic Position: Chr9, 27.75 cM, cytoband B
Alliance: Sdhdtm1Jlob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95252
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 2-4 were replaced with a neomycin resistance gene. (J:95252)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sdhd Mutation:  16 strains or lines available
References
Original:  J:95252 Piruat JI, et al., The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia. Mol Cell Biol. 2004 Dec;24(24):10933-40
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory