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Rsc1a1tm1Koep
Targeted Allele Detail
Nomenclature
Symbol: Rsc1a1tm1Koep
Name: regulatory solute carrier protein, family 1, member 1; targeted mutation 1, Hermann Koepsell
MGI ID: MGI:3526519
Synonyms: RS1-
Gene: Rsc1a1  Location: Chr4:141683851-141685599 bp, - strand  Genetic Position: Chr4, 74.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95148
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region was replaced by a neomycin selection cassette in reverse orientation. Northern blot of kidney samples from mutants demonstrated the absence of wild-type mRNA. Western blot indicated the absence of protein in mutant kidney and intestine. (J:95148)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rsc1a1 Mutation:  8 strains or lines available
References
Original:  J:95148 Osswald C, et al., Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol. 2005 Jan;25(1):78-87
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory