About   Help   FAQ
Targeted Allele Detail
Symbol: Fstl3tm1Alsc
Name: follistatin-like 3; targeted mutation 1, Alan Schneyer
MGI ID: MGI:3526450
Synonyms: FSLT3 KO
Gene: Fstl3  Location: Chr10:79777274-79782630 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Increased pancreatic islet size in Fstl3tm1Alsc/Fstl3tm1Alsc mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:119526
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neomycin selection cassette was inserted 5' to exon 1 and a third loxP site was inserted in intron 1. Subsequent mating to mice carrying a cre expressing transgene resulted in excision of both the neo selection cassette and exon 1. QPCR and Northern blot analysis confirmed the absence of transcription. (J:119526)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fstl3 Mutation:  3 strains or lines available
Original:  J:119526 Mukherjee A, et al., FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1348-53
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory