Fstl3tm1Alsc
Targeted Allele Detail
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Symbol: |
Fstl3tm1Alsc |
Name: |
follistatin-like 3; targeted mutation 1, Alan Schneyer |
MGI ID: |
MGI:3526450 |
Synonyms: |
FSLT3 KO |
Gene: |
Fstl3 Location: Chr10:79613108-79618464 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
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Alliance: |
Fstl3tm1Alsc page
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Increased pancreatic islet size in Fstl3tm1Alsc/Fstl3tm1Alsc mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:119526
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A floxed neomycin selection cassette was inserted 5' to exon 1 and a third loxP site was inserted in intron 1. Subsequent mating to mice carrying a cre expressing transgene resulted in excision of both the neo selection cassette and exon 1. QPCR and Northern blot analysis confirmed the absence of transcription.
(J:119526)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fstl3 Mutation: |
18 strains or lines available
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Original: |
J:119526 Mukherjee A, et al., FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1348-53 |
All: |
6 reference(s) |
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