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Fstl3tm1Alsc
Targeted Allele Detail
Nomenclature
Symbol: Fstl3tm1Alsc
Name: follistatin-like 3; targeted mutation 1, Alan Schneyer
MGI ID: MGI:3526450
Synonyms: FSLT3 KO
Gene: Fstl3  Location: Chr10:79777272-79782630 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Increased pancreatic islet size in Fstl3tm1Alsc/Fstl3tm1Alsc mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119526
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin selection cassette was inserted 5' to exon 1 and a third loxP site was inserted in intron 1. Subsequent mating to mice carrying a cre expressing transgene resulted in excision of both the neo selection cassette and exon 1. QPCR and Northern blot analysis confirmed the absence of transcription. (J:119526)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fstl3 Mutation:  9 strains or lines available
References
Original:  J:119526 Mukherjee A, et al., FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1348-53
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory