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Aqp7tm1Tfun
Targeted Allele Detail
Nomenclature
Symbol: Aqp7tm1Tfun
Name: aquaporin 7; targeted mutation 1, Tohru Funahashi
MGI ID: MGI:3526441
Synonyms: Aqp7-
Gene: Aqp7  Location: Chr4:41033074-41048139 bp, - strand  Genetic Position: Chr4, 20.83 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95278
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced 8 kb of sequence including exon 1-3 and the translation start sites. Northern blot analysis of WAT, BAT, kidney and liver of mutant mice demonstrated successful gene ablation. (J:95278)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aqp7 Mutation:  19 strains or lines available
References
Original:  J:95278 Maeda N, et al., Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory