Aif1^tm1Nsib
Targeted Allele Detail

Summary

• Symbol: Aif1^tm1Nsib
• Name: allograft inflammatory factor 1; targeted mutation 1, Nicholas Sibinga
• MGI ID: MGI:3526421
• Gene: Aif1 Location: Chr17:35389967-35394977 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Aif1^tm1Nsib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204462
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with an ATG-lacZ-PGK-neo cassette derived from the pSL1180 vector. Western blot analysis confirmed the asbence of protein expression in the liver, spleen, testis and thymus. (J:204462)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aif1 Mutation: 35 strains or lines available

References

• Original: J:204462 Casimiro I, et al., Genetic inactivation of the allograft inflammatory factor-1 locus. Genesis. 2013 Oct;51(10):734-40
• All: 5 reference(s)